蔡志雄

蔡志雄，福建医科大学孟超肝胆医院/福建省联合创新重点实验室，助理研究员。主要从事精准医学与肿瘤免疫方面的基础与临床研究。主持国家自然科学基金青年项目，国家自然科学区域创新发展联合基金（联合单位主持），福建省自然面上项目等省部厅级课题14项，作为核心成员参与国家科学仪器研发重大专项子项目等12项国家和省部级课题。共发表SCI论文50篇，以第一作者或通讯作者在Clinical Cancer Research，Molecular Cancer，Journal for immunotherapy of cancer，Advanced Healthcare Materials等国际高影响力SCI期刊发表论文17篇，相关研究成果获得2019年福建科学技术进步一等奖等。

研究方向：

肿瘤新生抗原、肿瘤精准治疗、液态活检

主持科研项目：

1. 国家自然科学基金委员会, 联合基金项目, U22A20328, 脾脏靶向新生抗原疫苗用于肝癌精准免疫治疗研究, 2023-01-01 至 2026-12-31, 联合单位主持。

2. 国家自然科学基金委员会, 青年科学基金项目, 81802413, 环状RNA circ ADAMTS13/miRNA /ADAMTS13信号轴在肝癌发生发展中的分子机制研究, 2019-01-01 至 2021-12-31, 主持。 

3. 福建省科技厅, 福建省自然科学基金面上项目, 2022J011280, CD8组织驻留性T细胞介导肝癌免疫治疗的作用机制研究, 2022-03 至 2025-03, 主持。

4. 福建省科技厅, 福建省科技创新联合资金项目, 2020Y9044, 基于新生抗原疫苗的精准免疫疗法联合PD-1抗体治疗肝细胞癌的分子机制研究, 2021-08 至 2024-08, 主持。 

5. 福建省卫健委，中青年骨干人才培养项目，2021GGA066，新抗原疫苗联合PD-1抗体通过招募组织驻留性T细胞增强肝癌免疫治疗的作用机制研究，2020-01至2024-12，主持。

6. 福州市科技局, 福州市对外科技合作项目, 2022-Y-006, 基于新生抗原多肽疫苗的综合免疫治疗体系改善胰腺癌治疗疗效的作用机制研究, 2022-06 至 2024-06, 主持。 

7. 福州市科技局, 福州市科技计划项目, 2021-S-113, 基于新生抗原的精准免疫疗法对肝细胞癌的治疗作用机制研究, 2021-06 至 2024-06, 主持。

8. 福州市卫生健康系统, 福州市卫生健康系统科技计划团队项目, 2022-S-wt2, 肿瘤新抗原 mRNA 疫苗治疗肝癌的疗效与作用机制研究, 2023-01 至 2025-12, 主持。

9. 福州市卫生健康系统, 福州市卫生健康系统科技计划团队项目, 2019-S-wt3, 基于无创的循环肿瘤DNA 液态活检技术实时追踪肝癌克隆结构变化的研究, 2019-06 至 2022-05, 主持。

10. 福建省科技厅, 福建省自然科学基金面上项目, 2017J01161, 循环肿瘤DNA评估肝癌异质性及追踪肿瘤发生发展的研究, 2017-04 至 2020-04, 主持。

11. 福建医科大学启航基金项目，2016QH082， 循环肿瘤DNA实时监测进展期肝癌病人肿瘤负荷的研究，2016-10至2019-06，5万元，主持。

12. 福州市科技计划项目，2015-S-143-16，半乳糖凝集素-4表达失调与原发性肝细胞癌复发转移的关系及相关分子机制研究，2015-04至2018-03，主持。

13. 福州市卫生系统科技计划项目，2014-s-w23，胞外galectin-4作为HBV相关肝癌预后血清标志物的临床基础研究，2014-09至2016-08，主持。

14. 福州市卫生系统科技计划项目，2013-S-wq20，Galectin-4在肝癌术后预后的临床应用研究，2014-01至2015-12，主持。

代表性论文：

1. Chen Hengkai^#; Li Zhenli^#; Qiu Liman; Dong Xiuqing; Chen Geng; Shi Yingjun; Cai Linsheng;Liu Wenhan; Ye Honghao; Zhou Yang; Ouyang Jiahe; Cai Zhixiong * ; Liu Xiaolong * ; Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T-cell infltration in preclinical hepatocellular carcinoma models, Journal for ImmunoTherapy of Cancer, 2022, 10: e004389

1. Cai Zhixiong^# ; Su Xiaoping^#; Qiu Liman^#; Li Zhenli^#; Li Xiaolou; Dong Xiuqing; Wei Fuqun; Zhou Yang; Luo Liuping; Chen Geng; Chen Hengkai; Wang Yingchao; Zeng Yongyi *; Liu Xiaolong * ; Personalized neoantigen vaccine prevents postoperative recurrence in hepatocellular carcinoma patients with vascular invasion, Molecular cancer, 2021, 2021(20): 164

2. Cai Zhixiong^#; Zhang Jun^#; He Yijing^#; Xia Lin^#; Dong Xiuqing; Chen Gen; Zhou Yan; Hu Xinlei; Zhong Shen; Wang Yingchao; Chen Hengkai; Xie Dan; Liu Xiaolong*; Liu Jingfeng* ; Liquid biopsy by combining 5-hydroxymethylcytosine signatures of plasma cell-free DNA and protein biomarkers for diagnosis and prognosis of hepatocellular carcinoma, ESMO Open, 2021, 6(1): 100021

3. Xiuqing Dong^#, Geng Chen^#, Xinghui Huang^#, Zhenli Li, Fang Peng, Hengkai Chen, Yang Zhou, Lei He, Liman Qiu, Zhixiong Cai*, Jingfeng Liu*, Xiaolong Liu*；Copy number profiling of circulating free DNA predicts transarterial chemoembolization response in advanced hepatocellular carcinoma，Molecular oncology, 2022,16(10) :1986-1999.

4. Yuanchang Fang^#, Geng Chen^#, Feng Chen, En Hu, Xiuqing Dong, Zhenli Li, Lei He, Yupeng Sun, Liman Qiu, Haipo Xu, Zhixiong Cai*, Xiaolong Liu*, Accurate transcriptome assembly by Nanopore RNA sequencing reveals novel functional transcripts in hepatocellular carcinoma, Cancer Science, 2021,12(9):3555-3568.

5. Feng Chen, Lei He, Liman Qiu, Yang Zhou,Zhenli Li, Geng Chen,Fuli Xin, Xiuqing Dong, Haipo Xu, Gaoxiong Wang*, Jingfeng Liu, Zhixiong Cai*. Circular RNA CircEPB41L2 Functions as Tumor Suppressor in Hepatocellular Carcinoma Through Sponging miR-590-5p, Cancer Management and Research, 2021,13:2969-2981.

6. Zhixiong Cai^#, Geng Chen^#, Yongyi Zeng, Xiuqing Dong, Zhenli Li, Yanbing Huang, Fuli Xin, Liman Qiu, Haipo Xu, Wei Zhang, Xiaoping Su, Xiaolong Liu *, Jingfeng Liu *, Comprehensive liquid profiling of circulating tumor DNA and protein biomarkers in long-term follow-up patients with hepatocellular carcinoma, Clinical cancer research,2019, 25:5284-5294.

7. Zhixiong Cai^#, Fuli Xin^# , Zuwu Wei, Ming Wu, Da Zhang, Xinyi Lin, Yunzhu Chen, Zhenxi Zhang, Xiaolong Liu, Cuiping Yao, Photodynamic therapy combined with anti-hypoxic signaling and CpG adjuvant as in-situ immunostimulant based on Metal-Organic Framework nanoparticles to boost cancer immunotherapy, Advanced Healthcare Materials ,2019, 201900996.

8. Ying Liu, Bingheng Lu, Zhixiong Cai *, Recent Progress on Mg- and Zn-Based Alloys for Biodegradable Vascular Stent Applications, journal of nanomaterials,2019, 1310792.

9. Liman Qiu^#, Yanbing Huang^#, Zhenli Li^#, Xiuqing Dong, Geng Chen, Haipo Xu, Yongyi Zeng, Zhixiong Cai*, Xiaolong Liu*, Jingfeng Liu*, Circular RNA profiling identifies circADAMTS13 as a miR-484 sponge which suppresses cell proliferation in hepatocellular carcinoma, Molecular oncology,2018,13: 441-455.

10. Geng Chen ^#, Zhixiong Cai ^#, Zhenli. Li, Dong Xiuqing., Xu Haipo., Lin Jianling., Chen Lihong., Huqin Zhang, Xiaolong Liu *, Jingfeng Liu *. Clonal evolution in long-term follow-up patients with hepatocellular carcinoma., International Journal of Cancer, 2018,143: 2862-2870.

11. Zhenli Li ^#, Geng Chen ^#, Zhixiong Cai ^#, Xiuqing Dong, Liman Qiu, Haipo Xu, Yongyi Zeng, Xiaolong Liu* , Jingfeng Liu*, Genomic and transcriptional Profiling of tumor infiltrated CD8+ T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma, OncoImmunology, DOI: 10.1080/2162402X.2018.1538436

12. Xiuqing Dong ^#, Geng Chen ^#, Zhixiong Cai ^#, Zhenli Li, Liman Qiu, Haipo Xu, Yuan Yuan., Xiaolong Liu*, Jingfeng Liu*, CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients., Cell. Physiol. Biochem., 2018, 47: 2602-2612.

13. Zhixiong Cai^#, Geng Chen^#, Yongyi Zeng, Xiuqing Dong, Minjie Lin, Xinhui Huang, Da Zhang, Xiaolong Liu*, Jingfeng Liu* , Circulating tumor DNA profiling reveals clonal evolution and real-time disease progression in advanced hepatocellular carcinoma, International Journal of Cancer, 2017,141: 977–985.

14. Zhixiong Cai^#, Da Zhang^#, Xinyi Lin, Yunzhu Chen, Ming Wu, Zuwu Wei, Zhenxi Zhang, Xiaolong Liu, Cuiping Yao, Glutathione responsive micelles incorporated with semiconducting polymer dots and doxorubicin for cancer photothermal-chemotherapy, Nanotechnology, 2017, 28: 425102.

15. Cancan Chen#, Gaoxiong Wang#, Xinhui Huang , Xiuqing Dong, Geng Chen , Mingjie Lin, Zhixiong Cai* and Yongyi Zeng*, Overexpression of galectin-4 promotes cell growth of hepatocellular carcinoma cells in vitro and in vivo, International Journal of Clinical and Experimental Pathology, 2017;10:10233-10242.

16. Zhixiong Cai, Yongyi Zeng, Bo Xu, Yunzhen Gao, Sen Wang, Jinhua Zeng, Lihong Chen, Aimin Huang, Xiaolong Liu* and Jingfeng Liu*, Galectin-4 serves as a prognostic biomarker for the early recurrence/metastasis of hepatocellular carcinoma, Cancer Science, 2015,105: 1510-1088.