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团队成员

蔡志雄

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蔡志雄,福建医科大学孟超肝胆医院/福建省联合创新重点实验室,助理研究员。主要从事精准医学与肿瘤免疫方面的基础与临床研究。 主持国家自然科学基金青年项目,福建省自然科学基金面上项目等省部级课题3项,以第一作者或通讯作者在Clinical Cancer Research、International Journal of Cancer、 Molecular Oncology、Cancer Science等国际知名期刊发表SCI论文11篇, 授权国家发明专利1项。

研究方向:

液体活检、新生抗原免疫治疗


主持承担的科研项目:

1. 国家自然科学基金青年项目,81802413,环状RNA circADAMTS13/miRNA/ADAMTS13信号轴在肝癌发生发展中的分子机制研究,2019/01-2021/12, 21万元,在研,主持。

2.福建省自然科学基金计划项目,2017J01161,循环肿瘤DNA评估肝癌异质性及追踪肿瘤发生发展的研究, 2017/04-2020/04, 4万元,在研,主持。

3.福州市卫生健康系统科技计划项目,2019-S-wt3,基于无创的循环肿瘤 DNA 液态活检技术实时追踪肝癌克隆结构变化的研究,2019/06-2022/05,8万元,在研,主持。

代表性论文:

(1) Zhixiong Cai#, Geng Chen#, Yongyi Zeng, Xiuqing Dong, Zhenli Li, Yanbing Huang, Fuli Xin, Liman Qiu, Haipo Xu, Wei Zhang, Xiaoping Su, Xiaolong Liu *, Jingfeng Liu *, Comprehensive liquid profiling of circulating tumor DNA and protein biomarkers in long-term follow-up patients with hepatocellular carcinoma, Clinical cancer research,2019, 25:5284-5294.

(2) Zhixiong Cai#, Fuli Xin#, Zuwu Wei, Ming Wu, Da Zhang, Xinyi Lin, Yunzhu Chen, Zhenxi Zhang, Xiaolong Liu, Cuiping Yao, Photodynamic therapy combined with anti-hypoxic signaling and CpG adjuvant as in-situ immunostimulant based on Metal-Organic Framework nanoparticles to boost cancer immunotherapy, Advanced Healthcare Materials,2019,

(3) Ying Liu, Bingheng Lu, Zhixiong Cai *, Recent Progress on Mg- and Zn-Based Alloys for Biodegradable Vascular Stent Applications, journal of nanomaterials,2019,

(4) Liman Qiu#, Yanbing Huang#, Zhenli Li#, Xiuqing Dong, Geng Chen, Haipo Xu, Yongyi Zeng, Zhixiong Cai*, Xiaolong Liu*, Jingfeng Liu*, Circular RNA profiling identifies circADAMTS13 as a miR-484 sponge which suppresses cell proliferation in hepatocellular carcinoma, Molecular oncology,2018,13: 441-455.

(5) Geng Chen #, Zhixiong Cai #, Zhenli. Li, Dong Xiuqing., Xu Haipo., Lin Jianling., Chen Lihong., Huqin Zhang, Xiaolong Liu *, Jingfeng Liu *. Clonal evolution in long-term follow-up patients with hepatocellular carcinoma., International Journal of Cancer, 2018,143: 2862-2870.

(6)Zhenli Li #, Geng Chen #, Zhixiong Cai #, Xiuqing Dong, Liman Qiu, Haipo Xu, Yongyi Zeng, Xiaolong Liu* , Jingfeng Liu*, Genomic and transcriptional Profiling of tumor infiltrated CD8+ T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma, OncoImmunology, DOI: 10.1080/2162402X.2018.1538436

(7) Xiuqing Dong #, Geng Chen #, Zhixiong Cai #, Zhenli Li, Liman Qiu, Haipo Xu, Yuan Yuan., Xiaolong Liu*, Jingfeng Liu*, CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients., Cell. Physiol. Biochem., 2018, 47: 2602-2612.

(8) Zhixiong Cai#, Geng Chen#, Yongyi Zeng, Xiuqing Dong, Minjie Lin, Xinhui Huang, Da Zhang, Xiaolong Liu*, Jingfeng Liu* , Circulating tumor DNA profiling reveals clonal evolution and real-time disease progression in advanced hepatocellular carcinoma, International Journal of Cancer, 2017,141: 977–985.

(9) Zhixiong Cai#, Da Zhang#, Xinyi Lin, Yunzhu Chen, Ming Wu, Zuwu Wei, Zhenxi Zhang, Xiaolong Liu, Cuiping Yao, Glutathione responsive micelles incorporated with semiconducting polymer dots and doxorubicin for cancer photothermal-chemotherapy, Nanotechnology, 2017, 28: 425102.

(10) Cancan Chen#, Gaoxiong Wang#, Xinhui Huang , Xiuqing Dong, Geng Chen , Mingjie Lin, Zhixiong Cai* and Yongyi Zeng*, Overexpression of galectin-4 promotes cell growth of hepatocellular carcinoma cells in vitro and in vivo, International Journal of Clinical and Experimental Pathology, 2017;10:10233-10242.

(11) Zhixiong Cai, Yongyi Zeng, Bo Xu, Yunzhen Gao, Sen Wang, Jinhua Zeng, Lihong Chen, Aimin Huang, Xiaolong Liu* and Jingfeng Liu*, Galectin-4 serves as a prognostic biomarker for the early recurrence/metastasis of hepatocellular carcinoma, Cancer Science, 2015,105: 1510-1088.