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陈耕

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陈耕:理学硕士,助理研究员。毕业于北京大学,福建医科大学孟超肝胆医院就职。目前主要从事于肿瘤二代测序的生物信息学数据分析及肝癌相关精准医疗与诊断预后标志物筛选等研究工作。目前主持省自然科学基金项目一项,福州市级科技课题一项,同时参与多项国家自然科学基金、福建省科技重大专项子项目等国家和省部级课题。发表SCI论文10余篇,其中以第一作者身份在IJC, Clinical Cancer Research,Nuclear Acid Research等国际知名期刊发表SCI论文9篇。

研究方向:

生物信息学 肿瘤基因组学 液态活检

 

主持承担的科研项目

福建省自然科学基金计划项目,2018J01145,基于二代测序技术的肝癌基因组突变特 征的研究,2018/4-2021/46万元,在研,主持。

福州市卫生系统科技计划项目,2015-S-143-21,肝癌中差异表达的lncRNA及其相互作 用miRNA的生物信息学分析,2015/4-2018/33万元,已结题,主持。

 

代表性论文

(1) Geng Chen#; Zhixiong Cai#; Zhenli Li; Xiuqing Dong; Haipo Xu; Jianling Lin; Lihong Chen; Huqin Zhang; Xiaolong Liu*; Jingfeng Liu*; Clonal evolution in long-term follow-up patients with hepatocellular carcinoma, International Journal of Cancer, 2018, 143(11): 2862-2870.

(2) Cai, Zhi-Xiong#; Chen, Geng#; Zeng, Yong-Yi; Dong, Xiu-Qing; Lin, Min-Jie; Huang, Xin-Hui; Zhang, Da; Liu, Xiao-Long* ; Liu, Jing-Feng* ; Circulati ng tumor DNA profiling reveals clonal evolution and real-time disease progression in advanced hepatocellular carcinoma., Int J Cancer, 2017, 141(5): 977-985.

(3) Cai, Zhixiong#; Chen, Geng#; Zeng, Yongyi; Dong, Xiuqing; Li, Zhenli; Huang, Yanbing; Xin, Fuli; Qiu, Liman; Xu, Haipo; Zhang, Wei; Su, Xiaoping; Liu, Xiaolong*; Liu, Jingfeng*; Comprehensive Liquid Profiling of Circulating Tumor DNA and Protein Biomarkers in Long-Term Follow-Up Patients with Hepatocellular Carcinoma , Clinical Cancer Research, 2019, 25(17): 5284-5294.

(4) Li, Zhenli#; Chen, Geng#; Cai, Zhixiong# ; Dong, Xiuqing; Qiu, Liman; Xu, Haipo; Zeng, Yongyi; Liu, Xiaolong*; Liu, Jingfeng*; Genomic and transcriptional Profiling of tumor infiltrated CD8(+) T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma , O NCOIMMUNOLOGY, 2019, 8(2): 0-e1538436.

(5) Dong Xiuqing#; Chen Geng#; Cai Zhixiong#; Li Zhenli; Qiu Liman; Xu Haipo; Yuan Yuan; Liu Xiaolong*; Liu Jingfeng*; CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients , Cellular Physiology and Biochemistry, 2018, 47(6): 2602-2612.