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刘小龙

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刘小龙:博士,研究员、硕博士生导师;福建医科大学孟超肝胆医院副院长西安交通大学、福州大学、福建医科大学、福建中医药大学兼职教授。曾于美国布朗大学进行联合博士培养,在美国布朗大学和瑞士巴塞尔大学进行博士后训练。2010年在瑞士巴塞尔大学生物中心工作获得固定研究职位Research Associate (staff scientist)主要从事肿瘤早期诊断新技术与新方法、免疫治疗与精准医学方面的基础与临床转化研究;兼任福建省医学会感染病学分会主任委员、福建省医学会肝病学分会委员、中国研究型医院学会生物治疗专业委员会全国委员,中国生物医学工程学会生物医学光子学分会全国委员、中国医师协会中西医结合医师分会基础与转化医学专业委员会常委等学术职务。现主持国家自然科学基金“国家重大科研仪器研制项目”、国家自然科学基金重点项目、面上项目、福建省科技重大专项等省部级科研项目17项;在相关领域的国际知名期刊上发表SCI收录论文100多篇,授权国家发明专利20项,公开国家发明专利21项。曾荣获德国洪堡学者奖学金(Alexander von Humboldt Fellowship,日本肿瘤学会“青年科学家奖”(Young Scientist Award)等多项荣誉。入选福州市引进高层次优秀人才,福建省青年拔尖创新人才,福州市优秀人才,福建省百人计划;荣获第三届“福州青年五四奖章标兵”、第十三届“福建青年五四奖章标兵”、第十三届“福建青年科技奖”,2017年 “福州市劳动模范”,2018年福建省卫生健康突出贡献中青年专家,2019年福建省科学技术进步一等奖(排名第二)2020年福建百千万人才工程省级推荐人选

 

研究方向:

肿瘤早期诊断新技术与新方法、免疫治疗、精准医学

 

主持承担的科研项目: 

2018.01-2022.12,基于波前整形的高光谱成像引导的肿瘤光热/光动力双模治疗手术系统,国家自然科学基金“国家重大科研仪器研制项目”(61727823),780万元,在研;

2018.01-2020.12“艾滋病和病毒性肝炎等重大传染病防治”专项,“ 乙肝相关肝癌精准诊疗标志物的研发与转化”(课题编号 2018ZX10302205),子课题“ 阻断及减缓乙肝到肝癌发展进程和提高肝癌治疗效果的精准医学技术”(2018ZX10302205-002),子任务:基于血浆游离DNA 驱动基因突变分析的乙肝相关肝癌治疗监测新策略研究,125万,在研;

2020.09-2023.08基于转移相关长链非编码RNA调控网络的肝细胞癌防治基础研究福建省科技创新联合资金项目(2019Y9047),100万,在研;

2020.11-2023.11,“肿瘤细胞端粒酶特异响应光学诊疗探针构建及应用研究”福建省自然科学基金重点项目(2020J02010),30万,在研。

荣誉与奖励:

1. 2008年,德国洪堡基金会,洪堡学者奖学金Alexander von Humboldt Fellowship

3. 2014年,福州市人民政府,第三批福州市引进高层次优秀人才;

4. 2014年,福建省委组织部,首批福建省青年拔尖创新人才;

5. 2014年,共青团福州市委,第三届“福州青年五四奖章标兵”;

6. 2015年,福建省科协,第十三届“福建青年科技奖”;

7. 2015年,日本肿瘤学会,“青年科学家奖”(Young Scientist Award);

8. 2016年,共青团福建省委,第十三届“福建青年五四奖章标兵”;

9.2016年,福州市人民政府,第三届“福州市优秀人才”;

10. 2017年,福州市总工会,福州市劳动模范;

11. 2018年,福建省委组织部,福建省第六批引进高层次创业创新人才(福建省百人计划);

12. 2019年,福建省卫生健康突出贡献中青年专家;

13. 2019年,肝细胞癌早期诊断与预后判断的分子标志物筛选及临床应用,福建省科技进步一等奖(排名第二)

学术兼职:

1.福建省医学会感染病学分会,主任委员

1. 福建省医学会肝病学分会,委员;青年委员会,副主任委员(第四届);

2. 中国研究型医院学会生物治疗专业委员会,全国委员(第一届);

3. 中国生物医学工程学会生物医学光子学分会,全国委员(第二届);

4. 中国抗癌协会抗癌药物专业委员会,常务委员

5. 中国医师协会临床精准医疗专业委员会青年委员会,委员(第一届);

6. 中国医师协会中西医结合医师分会基础与转化医学专业委员会,常委(第一届);

7. 福建省药理学会,理事(第二届);

8. “实用肝脏病”杂志,编委(第五届,2016-2019);

9. Combinatorial Chemistry & High Throughput Screening”,客座编辑2016);

10. World Journal of Gastroenterology”,编委(Editorial Board Member, 2016/12/01-2021/12/31),http://www.wjgnet.com/1007-9327/SearchMembers?siteName=1007-9327&pageNumber=1&type=4&text=XIAO-LONG%20LIU SCIIF3.3

代表性论文: 

D Zheng#, P Yu#, Z Wei, C Zhong, M Wu*, X Liu*. RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near?Infrared Photoacoustic Imaging and Photothermal Therapy. Nano-Micro Letters, 2020, 12:94, DOI: 10.1007/s40820-020-00429-x. (通讯作者)

Li Y#, Lin J#, Cai Z, Wang P, Luo Q, Yao C, Zhang Y, Hou Z, Liu J*, Liu X*. Tumor microenvironment-activated self-recognizing nanodrug through directly tailored assembly of small-molecules for targeted synergistic chemotherapy. J Control Release. 2020321:222-235. (通讯作者)

Z Cai#, F Xin#, Z Wei, M Wu, X Lin, Xi Du, G Chen,  D Zhang, Z Zhang, X Liu*and C Yao*. Photodynamic therapy combined with anti-hypoxic signaling and CpG adjuvant as in-situ immunostimulant based on Metal-Organic Framework nanoparticles to boost cancer immunotherapy. Advanced Healthcare Materials, 2019, DOI: 10.1002/adhm.201900996. (通讯作者)

Li Y#, Lin J#, Wang P, Luo Q, Lin H, Zhang Y, Hou Z, Liu J*, Liu X*. Tumor Microenvironment Responsive Shape-Reversal Self-Targeting Virus-Inspired Nanodrug for Imaging-Guided Near-Infrared-II Photothermal Chemotherapy. ACS Nano. 2019, DOI: 10.1021/acsnano.9b05425. (通讯作者)

Zhang D, Zheng Y, Lin Z, Lan S, Zhang X, Zheng A, Li J, Liu G, Yang H, Liu X*, and Liu J*. Artificial Engineered Natural Killer Cells Combined with Antiheat Endurance as a Powerful Strategy for Enhancing Photothermal-Immunotherapy Efficiency of Solid Tumors. Small. 2019, 15(42):e1902636. doi: 10.1002/smll.201902636.  (通讯作者)

Z Cai, G Chen, Y Zeng, X Dong, Z Li, Y Huang, F Xin, L Qiu, X Liu* and J Liu*. Comprehensive liquid profiling of circulating tumor DNA and protein biomarkers in long-termed follow-up patients with hepatocellular carcinoma. Clinical Cancer Research, 2019, DOI: 10.1158/1078-0432.CCR-18-3477. (通讯作者)

B Zhao, Y Wang, X Tan, X Zheng, K Ke, F Wang, N Liao, Z Cai, Y Shi, Y Zheng, Y Gao, Q Li, A Huang*, and X Liu*. Inflammatory microenvironment contributes to self-renewal features of hepatocellular carcinoma via NF-κB/miR-497/SALL4 axis. Molecular Therapy-Oncolytics, 2019, 15: 79-90. DOI: 10.1016/j.omto.2019.08.009. (通讯作者)

D Zhang, C Zhang, S Lan, Y Huang, J Liu, J Li*, X Liu* and H Yang*. Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy. Small, 2019, 1901176, 1-10. (通讯作者)

B Zhao#, Y Wang#, X Tan, K Ke, C Zhang, Y Gao, N Liao, Y Dang, Y Shi, Y Zheng, X Liu*, and J Liu*. An optogenetic engineered SUPER-T cell for hepatocellular carcinoma therapy. Theranostics, 2019, 9(7):1837-1850. (通讯作者)

P Wang, X Wang, Q Luo, Y Li, X Lin, L Fan, Y Zhang, J Liu *, and X Liu*. Fabrication of Red Blood Cell Based Multi-model Theranostic Probes for the Second Near-infrared Window Fluorescent Imaging-guided Tumor Surgery and Photodynamic Therapy. Theranostics, 2019, 9(2), 369-380. doi:10.7150/thno.29817. (通讯作者)

M Wu, L Wu, J Li, D Zhang, S Lan, X Zhang, X Lin, G Liu, X Liu*, and J Liu*. Self-luminescing theranostic nanoreactors with intraparticle relayed energy transfer for tumor microenvironment activated imaging and photodynamic therapy. Theranostics, 2019, 9(1): 20-33. (通讯作者)

L Qiu#, Y Huang#, Z Li#, X Dong, G Chen, H Xu, Y Zeng, Z Cai*, X Liu* and J Liu*. Circular RNA Profiling Identifies circADAMTS13 as A miR-484 Sponge which Suppresses Cell Proliferation in Hepatocellular Carcinoma. Molecular Oncology, 2019, 13(2), 441-455. DOI: 10.1002/1878-0261.12424. (通讯作者)

Z Li#, G Chen#, Z Cai#, X Dong#, H Xu, J Lin, L Chen, H Zhang, X Liu*, and J Liu*. Genomic and transcriptional Profiling of tumor infiltrated CD8+ T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma. Oncoimmunology. 2018, 8(2):e1538436. DOI: 10.1080/2162402X.2018.1538436. (通讯作者)

D Zhang, Z Cai, N Liao, S Lan, M Wu, H Sun, Z Wei, J Li*, and X Liu*pH / Hypoxia Programmable Triggered Cancer Photo-Chemotherapy Based on Semiconducting Polymer dot hybridized Mesoporous Silica Framework. Chemical Science, 2018, 9(37):7390-7399. DOI: 10.1039/c8sc02408a. (通讯作者)

G Chen#, Z Cai#, Z Li, X Dong, L Qiu, M Lin, X Liu *, and J Liu *. Clonal evolution in advanced hepatocellular carcinoma patients. International Journal of Cancer, 2018, 141(5):977-985. DOI: 10.1002/ijc.31844. (通讯作者)

D Zhang, M Wu, Z Cai, N Liao, K Ke, H Liu, M Li, G Liu, H Yang, X Liu*, and J Liu*. FDA approved drug based metal-organic particles for microvesicle-mediated deep penetration and pH / NIR / hypoixa-programmable activated cancer photo-chemotherapy. Advanced Science, 2018, 5(2):1700648, DOI: 10.1002/advs.201700648. (通讯作者)

ZX Cai#, G Chen#, YY Zeng, XQ Dong, MJ Lin, XH Huang, D Zhang, XL Liu * and JF Liu *. Circulating tumor DNA profiling reveals clonal evolution and real-time disease progression in advanced hepatocellular carcinoma. International Journal of Cancer, 2017, 141(5): 977-985. DOI: 10.1002/ijc.30798. (通讯作者)

D Zhang, A Zheng, J Li, M Wu, Z Cai, L Wu, Z Wei, H Yang, X Liu*, and J Liu*.  Tumour micro-environment activitable self-assembled DNA hybrids for pH and redox dual-responsive chemotherapy / PDT treatment of Hepatocellular carcinoma. Advanced Science, 2017, 1600460, DOI: 10.1002/advs.201600460. (通讯作者)

 D Zhang, A Zheng, J Li, M Wu, L Wu, Z Wei, N Liao, X Zhang, Z Cai, H Yang, X Liu*, and J Liu*. Smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable intracellular prodrug release, photodynamic treatment and aggregation induced photothermal therapy in hepatocellular carcinoma. Theranostics, 2017, 7(1): 164-179. (通讯作者)

D Wei#, Y Zeng#, X Xing, X Han, X Liu* and J Liu*. Proteome Differences between Hepatitis B Virus Genotype-B- and Genotype-C-Induced Hepatocellular Carcinoma Revealed by iTRAQ-Based Quantitative Proteomics. J Proteome Research, 2016, 15: 487-498. DOI: 10.1021/acs.jproteome.5b00838. (通讯作者)

 

授权发明专利:

刘小龙,杨晓冬,张云,王毅婧。基于均相时间分辨荧光的检测重金属含量的方法。专利号:ZL201310075459.3

刘小龙,杨晓冬,张云,王毅婧。应用于水体重金属检测的检测液及使用方法。专利号:ZL201310074518.5

刘小龙,刘景丰,黄爱民。一种特异性快速检测环腺苷酸的试剂盒及检测方法。专利号:ZL201310316937.5;

刘小龙刘景丰,李正林,黄爱民。用于肝癌光热治疗和核磁影像的antiGPC3-PB NPs 

刘小龙刘景丰,张达,曾永毅。用于肿瘤早期诊断与光学治疗的多功能纳米胶束及其应用。发明专利,专利号:ZL201510429203.7;

刘小龙,赵必星,刘景丰,谭雄红。一种光调控T细胞活化的表达载体、构建方法及应用。发明专利,专利号:ZL 201610404536.9;