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张达

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张达,博士，硕士生导师，福建医科大学孟超肝胆医院副研究员。主要从事光学纳米诊疗、放疗纳米增敏剂及纳米疫苗等研发与其肝癌免疫治疗应用研究。已在Nano Letters, Angewandte Chemie, ACS Nano, Advanced Science, Small, iScience, Chemical Engineering Journal, Theranostics, Chemical Science, ACS applied materials & interfaces及科学通报等期刊发表SCI论文30篇，ESI高引论文3篇，公开国家发明专利11项（授权9项，第一发明人4项）； 2021年入选福建省高层次人才（C类）；2022年获福建省杰出青年；主持国自然基金青年项目1项，主持福建省科技创新联合资金及面上、杰青项目等4项；主持福建省中青年骨干项目1项；参与国家及重点项目等4项；2022年福建省科学技术进步奖一等奖（4/10）；2021年福建医学科技奖二等奖（4/7）；2022年福建自然科学优秀学术论文一等奖; 2022年福州市自然科学优秀学术论文一等奖；；2020年医学科技突出贡献工作者；2014年福州市十佳创新能手。

 

研究方向：

肿瘤新抗原/溶瘤免疫治疗、放疗与免疫治疗、纳米光学诊疗

 

主持科研项目：

1. 2019.01---2021.12，国家自然科学基金青年项目：智能核壳型金属有机配位聚合物用于磁共振引导的肿瘤近红外二区光热协同治疗(61805041)，25万元，主持，结题；

2. 2022.08.01---2025.08.01福建省自然科学基金杰青项目：新生抗原疫苗递送载体设计及其应用，2022J06034，30万，主持，在研；

3. 2022.10-2025.10，福建省科技创新联合资金项目：新型放疗增敏纳米材料提高肿瘤放射治疗效应的研究（交叉学科项目）, 2021Y9216，200万，主持，在研；

4. 2022.08---2024.08福建省卫健委中青年骨干项目：新生抗原疫苗胞质递送增强肝癌个性化免疫治疗，2021GGB020，5万，主持，在研；

5. 2020.11---2023.11，福建省自然科学基金面上项目：基于光敏配位聚合物调控肿瘤微环境增强肝癌光化学-免疫治疗研究(2020J011154)，7万元，主持，在研；

6. 2016/04-2019/04，福建省自然科学基金面上项目：还原性敏感光敏化DNA-AQ4N适配体用于靶向肝癌监测及光动力诱导乏氧性化疗联合治疗(2016J01174)，4万元，主持，结题；

7.  2015/04-2018/03，福州市科技计划项目：半导体聚合物纳米胶束用于肝癌光声-核磁共振成像及光学协同治疗的研究(2015-S-143-11)，5万元，主持，结题；

8.  2014/07-2017/06，福州市卫生系统科技计划项目：Gd/Au杂化脂质体作为肝癌靶向的CT/MRI双模态影像及热疗探针的应用研究(2014-S-w25)，4万元，主持，结题；

9.  2016/01-2019/12，国家自然科学基金面上项目： 肿瘤特异靶向的长循环多功能纳米胶束用于肝癌的光声成像及光热/光动力协同治疗研究(61575044)，60万元，参与，结题；

10.  2016/01-2019/12，国家自然科学基金“促进海峡两岸科技合作联合基金”：光声/MRI/CT多模态成像监测原发性肝癌靶向微创治疗(U1505221)，215万元，参与，结题；

11.  2018/01-2022/12，国家自然科学基金“国家重大科研仪器研制项目”：基于波前整形的高光谱成像引导的肿瘤光热/光动力双模治疗手术系统(61727823)，780万元，参与，在研；

12.  2020/01-2023/12, 国家自然科学基金重大研究计划“基于核酸适体的膀胱癌相关标志物发现和可视化分析(91959102)”80万，参与，在研；

 

荣誉与奖励：

2022年福建自然科学优秀学术论文一等奖;

2022年福州市自然科学优秀学术论文一等奖;

2022年福建省科学技术进步奖一等奖（排名第四）;

2021年福建医学科技奖二等奖（排名第四）；

2020年医学科技突出贡献工作者；

2014年福州市十佳创新能手；

 

学术兼职：

中国抗癌协会抗癌药物专业委员会，青年委员

《ACS Nano》、《Advanced Science》、《Small》、《Chemical Engineering Journal》、《ACS applied materials & interfaces》，《Biomaterials》、《Acta biaomaterials》等杂志审稿人。

 

代表性论文：

  1. Da Zhang*#, Chenwei Jiang#, Xiaoyuan Zheng#, Zhiwen Lin#, Qiuyu Zhuang, Huanzhang Xie, Yuzhi Liang, Yu Xu, Linsheng Cui, Xiaolong Liu*, Yongyi Zeng*. Normalization of Tumor Vessels by Lenvatinib-Based Metallo-Nanodrugs Alleviates Hypoxia and Enhances Calreticulin-Mediated Immune Responses in Orthotopic HCC and Organoids. Small (2023): 2207786 (IF: 15.153, 一区)

  2. Ming Wu#, Hao Li#, Cao Zhang, Yingchao Wang, Cuilin Zhang, Yuting Zhang, Aoxue Zhong, Da Zhang*, Xiaolong Liu*. Silk-Gel Powered Adenoviral Vector Enables Robust Genome Editing of PD-L1 to Augment Immunotherapy across Multiple Tumor Models. Advanced Science (2023): 2206399. (IF: 17.521, 一区)

  3. Qingfu Zhao#, Yunhao Wang#, Binyu Zhao#, Hengkai Chen, Zhixiong Cai, Youshi Zheng, Yongyi Zeng, Da Zhang*, and Xiaolong Liu* Neoantigen Immunotherapeutic-Gel Combined with TIM-3 Blockade Effectively Restrains Orthotopic Hepatocellular Carcinoma Progression. Nano Lett. 2022. 9;22(5):2048-2058. (IF: 11.189, 一区, TOP)

  4. Yunhao Wang#, Qingfu Zhao#, Binyu Zhao, Youshi Zheng, Qiuyu Zhuang, Naishun Liao, Peiyuan Wang, Zhixiong Cai, Da Zhang*, Yongyi Zeng*, Xiaolong Liu*. Remodeling Tumor-Associated Neutrophils to Enhance Dendritic Cell-Based HCC Neoantigen Nano-Vaccine E?ciency. Advanced Science. 2022, 2105631. (IF: 17.521, 一区)

  5. Zhijin Fan, Cheng Jiang, Yichao Wang, Kaiyuan Wang, Jade Marsh, Da Zhang*, Xin Chen*, Liming Nie* Engineered Extracellular Vesicles as Intelligent Nanosystem for Next-Generation of Nanomedicine, Nanoscale Horiz, 2022,7, 682-714. (IF: 11.684, 一区)

  6. Da Zhang#, Youshi Zheng#, Ziguo Lin, Xiaolong Liu, Juan Li*, Huanghao Yang*, Weihong Tan. Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking for Enhanced Adoptive Immunotherapy in Solid Tumors. Angew Chem Int Ed Engl.2020.59,12022-12028. (IF: 16.823, 一区, TOP)

  7. Da Zhang#, Ziguo Lin#, Ming Wu#, Zhixiong Cai, Youshi Zheng, Lei He, Zhenli Li, Jie Zhou, Liqin Sun, Geng Chen, Yongyi Zeng, Juan Li, Jingfeng Liu*, Huanghao Yang*, Xiaolong Liu*.Cytosolic Delivery of Thiolated Neoantigen Nano-vaccine Combined with Immune Checkpoint Blockade to Boost Anti-cancer T Cell Immunity. Advanced Science. 2021. 8, 2003504. (IF: 17.521, 一区)

  8. Da Zhang#, Ziguo Lin#, Youshi Zheng, Jibin Song, Juan Li, Yongyi Zeng,* and Xiaolong Liu*. Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition. ACS Nano, 2020. 14, 8985-8999. (IF: 18.027, 一区)

  9. Chengyun Chen, Yuhong Tong, Youshi Zheng, Yingjun Shi, Zhaowei Chen, Juan Li, Xiaolong Liu, Da Zhang*, Huanghao Yang*. Cytosolic Delivery of Thiolated Mn-cGAMP Nanovaccine to Enhance the Antitumor Immune Responses. Small. 2021.2006970. (IF: 15.153, 一区) 

  10. Xianglian Liao, Youshi Zheng, Ziguo Lin, Yi Shen, Huiyun Lin, Xiaolong Liu, Da Zhang*, Buhong Li*. Self-assembled metallo-supramolecular nanoflowers for NIR / acidic-triggered multidrug release, long-term tumor retention and NIR-II fluorescence imaging-guided photo-chemotherapy. Chemical Engineering Journal. 2020. 400, 125882. (IF: 16.8, 一区)

  11. Da Zhang#, Youshi Zheng#, Ziguo Lin, Shanyou Lan, Xiaolong Zhang, Aixian Zheng, Juan Li, Gang Liu, Huanghao Yang, Xiaolong Liu*, Jingfeng Liu*. Artificial Engineered Natural Killer Cells Combined with Antiheat Endurance as Powerful Strategy for Enhancing Photothermal- Immunotherapy Efficiency of Solid Tumors. Small. 2019. 15, 1970228. (IF: 15.153, 一区)

  12. Da Zhang# , Cuilin Zhang# , Shanyou Lan, Yanbing Huang, Jingfeng Liu, Juan Li*, Xiaolong Liu*, Huanghao Yang* Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy. Small. 2019. 15, 1901176. (IF: 15.153, 一区)

  13. Da Zhang#, Ming. Wu, Zhixiong Cai, Naishun Liao, Kun Ke, Hongzhi Liu, Ming Li, Gang Liu, Huanghao Yang, Xiaolong Liu* , Jingfeng Liu*. Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle-Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy. Advanced Science, 2018. 5, 1700648. (IF: 17.521, 一区)

  14. Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Zhixiong Cai, Lingjie Wu, Zuwu Wei, Huanghao Yang, Gang Liu, Xiaolong Liu* , Jingfeng Liu*. Tumor Microenvironment Activable Self-Assembled DNA Hybrids for pH and Redox Dual-Responsive Chemotherapy / PDT Treatment of Hepatocellular Carcinoma, Advanced Science, 2017. 4, 1600460. (IF: 17.521, 一区)

  15. Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Lingjie Wu, Zuwu Wei, Naishun Liao, Xiaolong Zhang, Zhixiong Cai, Huanghao Yang, Gang Liu, Xiaolong Liu* , Jingfeng Liu*.Smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable intracellular prodrug release, photodynamic treatment and aggregation induced photothermal therapy of hepatocellular carcinoma. Theranostics, 2017, 7,164-179. (IF: 11.556, 一区)

  16. Da Zhang, Zhixiong Cai, Naishun Liao, Shanyou Lan, Ming Wu, Haiyan Sun, Zuwu Wei,Juan Li*, Xiaolong Liu*.pH / hypoxia programmable triggered cancer photo-chemotherapy based on a semiconducting polymer dot hybridized mesoporous silica framework. Chemical science, 2018. 9, 7390-7399. (IF: 9.825, 一区)

  17. Ming Wu#, Dongye Zheng#, Da Zhang #, Peiwen Yu, Lianli Peng, Feng Chen, Ziguo Lin,Zhixiong Cai, Jiong Li, Zuwu Wei, Xinyi Lin, Jingfeng Liu*, Xiaolong Liu*. Converting Immune Cold into Hot by Biosynthetic Functional Vesicles to Boost Systematic Antitumor Immunity. iScience, 2020. 23, 101341. (IF: 6.4, 二区)

  18. Da Zhang, Ming Wu., Yongyi Zeng, Lingjie Wu, Qingtang Wang, Xiao Han, Xiaolong Liu*, Jingfeng Liu*.Chlorin e6 conjugated poly (dopamine) nanospheres as PDT / PTT dual-modal therapeutic agents for enhanced cancer therapy, ACS applied materials & interfaces, 2015. 7, 8176- 8187. (IF: 10.383, 二区)

  19. Da Zhang, Hao Xu, Xiaolong Zhang, Yubin Liu, Ming Wu, Juan Li, Huanghao Yang, Gang Liu, Xiaolong Liu*, Jingfeng Liu*, Zhen Yuan. Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy. ACS applied materials & interfaces, 2018. 10, 25203-25212. (IF: 10.383, 二区)

  20. Shanyou Lan, Ziguo Lin, Da Zhang*, Yongyi Zeng*, Xiaolong Liu.  Photocatalysis Enhancement for Programmable Killing of Hepatocellular Carcinoma through Self-Compensation Mechanisms based on Black Phosphorus Quantum Dot hybridized Nanocatalysts, ACS applied materials & interfaces, 2019. 11, 9804-9813. (IF: 10.383, 二区)

授权发明专利

  1. 张达;刘景丰;刘小龙;吴名,一种PEG修饰的二维纳米片光热转换材料及其应用.专利号ZL 201710655253.6；

  2. 张达;刘小龙;吴名;刘景丰,肿瘤微酸性敏感的铜-药物共配位自组装纳米粒及应用.专利号ZL 201710102120.6；

  3. 张达;刘景丰;刘小龙;曾永毅,一种光敏纳米复合物及其制备方法和应用.专利号ZL 201811343150.7；

  4. 张达;曾永毅;刘景丰;刘小龙,黑磷量子点/铂杂化介孔二氧化硅纳米颗粒及制备方法和应用.专利号ZL 201811343125.9；

  5. 刘景丰;刘小龙;黄爱民; 张达, 用于肝癌多模态影像和光热治疗的多功能纳米探针及应用.专利号ZL 201310695697.4；

  6. 刘小龙;刘景丰; 张达;曾永毅, 用于肿瘤早期诊断与光学治疗的多功能纳米胶束及其应用. 专利号ZL 201510429203.7；

  7. 刘小龙; 张达;郑友世;蔡志雄;苏小平.一种人工改造自然杀伤性细胞及其制备与应用.专利号201910324655.7；

  8. 刘景丰;刘小龙;郑友世; 张达;曾永毅.一种增强NK细胞对肿瘤细胞靶向杀伤力的培养方法.专利号202010353458.0；

  9. 吴名; 张达;刘小龙;刘景丰;曾永毅.用于声动力/气体协同抗肿瘤治疗的仿生纳米材料及其制备方法.专利号202010555452.1；