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团队成员

张达

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张达:福建医科大学孟超肝胆医院特聘副研究员。主持国家自然科学基金青年基金项目,并参与国自然科学基金重大研究计划、重大仪器专项及国自然面上项目;同时。主持福建省自然科学面上项目,福州市科技局项目。在光学诊疗领域,化学及化学动力学治疗,纳米疫苗设计与过继性免疫治疗方面具有丰富的研究经验。以第一作者或通讯作者在国内外知名期刊如Angewandte Chemie, Chemical Science, Advanced Science, Small, Theranostics, ACS applied materials & interfaces, Materials Chemistry Frontiers, 科学通报等发表多篇SCI研究性论文,h-index 12,ESI高引论文2篇,公开国家发明专利3项(第一发明人)。

研究方向

光学诊疗、新生抗原纳米疫苗、肿瘤过继性免疫治疗


主持承担的科研项目:

1.  2019.01---2021.12,国家自然科学基金青年项目:智能核壳型金属有机配位聚合物用于磁共振引导的肿瘤近红外二区光热协同治疗(61805041),25万元,主持,在研;

2.  2016/04-2019/04,福建省自然科学基金面上项目:还原性敏感光敏化DNA-AQ4N适配体用于靶向肝癌监测及光动力诱导乏氧性化疗联合治疗(2016J01174),4万元,主持,结题;

3.  2015/04-2018/03,福州市科技计划项目:半导体聚合物纳米胶束用于肝癌光声-核磁共振成像及光学协同治疗的研究(2015-S-143-11),5万元,结题,主持,结题;

4.  2014/07-2017/06,福州市卫生系统科技计划项目:Gd/Au杂化脂质体作为肝癌靶向的CT/MRI双模态影像及热疗探针的应用研究(2014-S-w25),4万元,主持,结题;

5.  2014/01-2015/12,福州市卫生系统科技计划项目: GPC3抗体修饰普鲁士蓝纳米粒子用于肝癌靶向光热治疗(2013-S-wq17),2万元,主持,结题;

6.  2016/01-2019/12,国家自然科学基金面上项目: 肿瘤特异靶向的长循环多功能纳米胶束用于肝癌的光声成像及光热/光动力协同治疗研究(61575044),60万元,参与,结题;

 7.  2016/01-2019/12,国家自然科学基金“促进海峡两岸科技合作联合基金”:光声/MRI/CT多模态成像监测原发性肝癌靶向微创治疗(U1505221),215万元,参与,结题;

8.  2018/01-2022/12,国家自然科学基金“国家重大科研仪器研制项目”:基于波前整形的高光谱成像引导的肿瘤光热/光动力双模治疗手术系统(61727823),780万元,参与,在研;

9.  2020/01-2023/12, 国家自然科学基金重大研究计划“基于核酸适体的膀胱癌相关标志物发现和可视化分析”80万,参与(第二位),在研;


代表性论文:

1.       Da Zhang#, Youshi Zheng#, Ziguo Lin, Xiaolong Liu, Juan Li*, Huanghao Yang*, Weihong Tan, Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking for Enhanced Adoptive Immunotherapy in Solid Tumors, Angew Chem Int Ed Engl. 2020.3. doi: 10.1002/anie.202002145.

2.       Tianhong Teng#, Ronggui Lin#, Ziguo Lin, Kun Ke, Xianchao Lin, Maoen Pan, Da Zhang*, Heguang Huang*, Photothermal augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode, Biomaterials Science. 2020, DOI, 10.1039/D0BM00549E (通讯作者)

3.       Da Zhang, Youshi Zheng, Ziguo Lin, Shanyou Lan, Xiaolong Zhang, Aixian Zheng, Juan Li, Gang Liu, Huanghao Yang, Xiaolong Liu*, Jingfeng Liu*. Artificial Engineered Natural Killer Cells Combined with Antiheat Endurance as Powerful Strategy for Enhancing Photothermal-Immunotherapy Efficiency of Solid Tumors. Small. 2019. 15(42), 1970228. (Black inside Cover)

4.       Da Zhang#, Cuilin Zhang#, Shanyou Lan, Yanbing Huang, Jingfeng Liu, Juan Li*, Xiaolong Liu*, Huanghao Yang* Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy. Small. 2019. 1901176. (Black Cover)

5.       Shanyou Lan, Ziguo Lin, Da Zhang*, Yongyi Zeng*, Xiaolong Liu, Photocatalysis Enhancement for Programmable Killing of Hepatocellular Carcinoma through Self-Compensation Mechanisms based on Black Phosphorus Quantum Dot hybridized Nanocatalysts, ACS applied materials & interfaces, 2019. 11, 9804-9813. (通讯作者)

6.       Da Zhang#, Ziguo Lin#, Shanyou Lan, Haiyan Sun*, Yongyi Zeng* Xiaolong Liu*. The Design of Janus Black Phosphorus Quantum dots@Metal-Organic Nanoparticles for Simultaneously Enhancing Environmental Stability and Photodynamic therapy Efficiency, Mater. Chem. Front. 2019, 3, 656-663. (Hot paper) 

7.       Lin, K., Lin, Z., Li, Y., Zheng, Y., Zhang, D*. Ultrasound-induced reactive oxygen species generation and mitochondria-specific damage by sonodynamic agent/metal ion-doped mesoporous silica. RSC Advances, 2019, 9(68), 39924-39931. (通讯作者)

8.       Da Zhang, Hao Xu, Xiaolong Zhang, Yubin Liu, Ming Wu, Juan Li, Huanghao Yang, Gang Liu , Xiaolong Liu*, Jingfeng Liu*, Zhen Yuan. Self-Quenched Metal–Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging- Guided Second Near-Infrared Window Photochemotherapy. ACS applied materials & interfaces, 2018, 10, 25203-25212. (Front Cover)

9.       Da Zhang, Zhixiong Cai, Naishun Liao, Shanyou Lan, Ming Wu, Haiyan Sun,  Zuwu Wei, Juan Li*, Xiaolong Liu*. pH / hypoxia programmable triggered cancer photo-chemotherapy based on a semiconducting polymer dot hybridized mesoporous silica framework. Chemical science, 2018, 9, 7390-7399.

10.   Da Zhang#, Xiao Lin#, Shanyou Lan#, Haiyan Sun, Xuandong Wang, Xiaolong Liu, Yun Zhang, and Yongyi Zeng*. Localized Surface Plasmon Resonance Enhanced Singlet Oxygen Generation and Light Absorption Based on Black Phosphorus@AuNPs Nanosheet for Tumor Photodynamic/Thermal Therapy, Particle & Particle Systems Characterization, 2018, 35, 1800010.

11.   Da Zhang, Ming. Wu, Zhixiong Cai, Naishun Liao, Kun Ke, Hongzhi Liu, Ming Li, Gang Liu, Huanghao Yang, Xiaolong Liu*, Jingfeng Liu*. Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle-Mediated Deep Penetration and Programmable pH / NIR / Hypoxia Activated Cancer Photochemotherapy, Advanced Science, 2018, 5, 1700648. (ESI highly cited papers) 

12.   Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Zhixiong Cai, Lingjie Wu, Zuwu Wei, Huanghao Yang, Gang Liu, Xiaolong Liu*, Jingfeng Liu*. Tumor Microenvironment Activable Self-Assembled DNA Hybrids for pH and Redox Dual-Responsive Chemotherapy / PDT Treatment of Hepatocellular Carcinoma, Advanced Science, 2017, 4, 1600460.

13.   Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Lingjie Wu, Zuwu Wei, Naishun Liao, Xiaolong Zhang, Zhixiong Cai, Huanghao Yang, Gang Liu, Xiaolong Liu*, Jingfeng Liu*. Smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable intracellular prodrug release, photodynamic treatment and aggregation induced photothermal therapy of hepatocellular carcinoma, Theranostics, 2017, 7: 164-179.

14.   Cai, Z#., Zhang, D#., Lin, X., Chen, Y., Wu, M., Wei, Z., Z. X Zhang, X. L. Liu, Yao, C.. Glutathione responsive micelles incorporated with semiconducting polymer dots and doxorubicin for cancer photothermal-chemotherapy. Nanotechnology, 2017, 28, 425102.

15.   Da Zhang, Ming Wu, Yongyi Zeng, Naishun Liao, Zhixiong Cai, Gang Liu, Xiaolong Liu*, Jingfeng Liu*. Lipid micelles packaged with semiconducting polymer dots as simultaneous MRI / photoacoustic imaging and photodynamic / photothermal dual-modal therapeutic agents for liver cancer, Journal of Materials Chemistry B, 2016, 4, 589-599. (Front Cover).

16.   Da Zhang, Ming Wu., Yongyi Zeng,, Lingjie Wu, Qingtang Wang, Xiao Han, Xiaolong Liu*, Jingfeng Liu*. Chlorin e6 conjugated poly (dopamine) nanospheres as PDT / PTT dual-modal therapeutic agents for enhanced cancer therapy, ACS applied materials & interfaces, 2015, 7, 8176-8187. (ESI highly cited papers)


获得荣誉称号及奖励

1.      福州市十佳创新能手,2014年

2.      福建医科大学孟超肝胆医院优秀员工,2015, 2016, 2019年

3.      福建省自然科学优秀论文, 2018年

4.      2015-2016年度福州市自然科学优秀学术论文奖,2018年