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团队成员

张晓龙

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张晓龙:理学博士,福建医科大学孟超肝胆医院助理研究员、福州大学外聘硕士生导师。近年来主持国家自然科学基金青年基金、中国博士后面上资助、福建省自然科学基金青年项目、福建省科技创新联合资金项目、福建省卫计委中青年骨干人才培养项目等国家级、省市级相关科研项目多项。目前,主要从事肿瘤诊断分子影像探针和纳米药物的开发及应用,实现肿瘤的成像、光动力、光热或化学治疗等基础研究工作,在相关研究领域发表SCI收录论文10余篇。


研究方向

肿瘤分子影像探针开发与应用、肿瘤纳米药物合成与综合治疗


主持承担的科研项目:

1.      国家自然科学基金青年项目,21605021,核酸功能化聚吡咯纳米体系在肿瘤细胞靶向成像与治疗中的研究,2017/01-2019/12,20万。

2.      福建省自然科学基金-青年科技人才创新项目,2016J05206,核酸功能化荧光纳米探针在细胞内谷胱甘肽实时成像的研究,2016/4-2019/4,4万元。

3.      福建省科技创新联合资金项目,2016Y9060,功能纳米材料在肿瘤细胞靶向治疗及细胞凋亡成像中的应用研究,2016/9-2019/9,10万元。

4.      福建省卫生计生科研人才培养项目-中青年骨干人才培养项目, 2018-ZQN-75,肿瘤微环境响应纳米药物用于增强光动力治疗的研究,2018/5-2021/4,10万。

5.      福建省卫计委青年科研课题,2016-1-85,肿瘤细胞靶向的刺激响应型纳米药物构建,2016/10-2019/9,3万元。

6.      福州市科技计划项目-社会发展项目,2016-S-124-8,肿瘤细胞内信使RNA响应的靶向成像系统,2016/03-2018/03,3万元。

7.      福州市卫生计生系统科技计划项目-青年科研项目,2015-S-WQ11,贵金属纳米颗粒在肝癌标志物GPC3检测中的应用研究,2015/12-2018/11,2万元。


代表性论文:

1.       Xiaolong Zhang, Ming Wu, Jiong Li, Shanyou Lan, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, Light-enhanced hypoxia-response of conjugated polymer nanocarrier for successive synergistic photodynamic and chemo-therapy, ACS Appl. Mater. Interfaces, 2018, 10 (26), 21909–21919.

2.       Xiaolong Zhang, Xionghong Tan, Da Zhang, Naishun Liao, Youshi Zheng, Aixian Zheng, Yongyi Zeng, Xiaolong Liu *, Jingfeng Liu*, A cancer cell specific targeting nanocomplex for combination of mRNA-responsive photodynamic and chemo-therapy, Chemical Communications, 2017,53, 9979-9982.

3.       Xiaolong Zhang, Naishun Liao, Geng Chen, Aixian Zheng, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, A fluorescent turn on nanoprobe for simultaneous visualization of dual-targets involved in cell apoptosis and drug screening in living cells, Nanoscale, 2017, 9(30): 10861-10868.

4.       Xiaolong Zhang#, Yongyi Zeng#, Aixian Zheng, Zhixiong Cai, Aimin Huang, Jinhua Zeng, Xiaolong Liu*, Jingfeng Liu*, A fluorescence based immunoassay for galectin-4 using gold nanoclusters and a composite consisting of glucose oxidase and a metal-organic framework, Microchim Acta, 2017, 184,1933–1940.

5.       Xiao-Long Zhang, Cheng Zheng, Yun Zhang, Huang-Hao Yang, Xiaolong Liu*, Jingfeng Liu*, One-pot synthesis of gold nanostars using plant polyphenols for cancer photoacoustic imaging and photothermal therapy, J Nanopart Res, 2016, 18:174.

6.       Xiao-Long Zhang, Cheng Zheng, Shan-Shan Guo, Juan Li*, Huang-Hao Yang*, Guonan Chen, Turn-on fluorescence sensor for intracellular imaging of glutathione using g-C3N4 nanosheet-MnO2 sandwich nanocomposite. Analytical Chemistry, 2014, 86(7): 3426-3434.

7.        Cuiping Yao#, Jing Wang#, Aixian Zheng, Lingjie Wu, Xiaolong Zhang?, Xiaolong Liu*, A fluorescence sensing platform with the MnO2 nanosheets as an effective oxidant for glutathione detection. Sensors and Actuators B: Chemical, 2017, 252, 30-36.

8.       Jing Wang#, Cheng Zheng#, Xionghong Tan, Aixian Zheng, Yongyi Zeng, Zhenxi Zhang, Xiaolong Zhang,* Xiaolong Liu*, Sensitive fluorometric determination of glutathione using fluorescent polymer dots and the dopamine-melanin nanosystem, Microchimica Acta, 2019, 186(8):568.

9.       Xionghong Tan, Zheng Li, Yanlin Du, Aixian Zheng, Yongyi Zeng, Xiaolong Zhang*, Xiaolong Liu*, Niancai Peng*, A MnO2 nanosheets-o-phenylenediamine oxidative system for the sensitive fluorescence determination of alkaline phosphatase activity, Anal. Methods, 2018, 10, 5341-5346.