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团队成员

赵必星

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赵必星: 细胞生物学博士,副研究员。福建医科大学孟超肝胆医院肝病研究所副所长。福州大学兼职副教授、硕士生导师。福建省医学会肝病学分会青年委员会副主任委员、中国抗癌协会抗癌药物专业委员会青年委员会委员、中国医师协会中西医结合医师分会基础与转化医学专业委员会委员。主持国家自然科学基金面上项目等多项国家级和省市级研究课题。在相关领域的国际知名期刊上发表SCI收录论文三十多篇。曾获得福建省自然科学一等奖、厦门市科学技术进步一等奖、福州市青年科技奖、福建省自然科学优秀学术论文二等奖等荣誉。


研究方向:

肿瘤相关细胞信号转导通路、免疫治疗与精准医学


主持承担的科研项目:

1. 国家自然科学基金面上项目(81672376),SALL4及其相互作用蛋白对肝癌治疗抗性的调控功能研究,2017/01-2020/12,57万元,在研。

2. 福建省卫生教育联合攻关计划项目(2019-WJ-19),长链非编码RNA FAM99A在缺氧诱导的肝癌转移中的作用及机制研究,2019/09-2022/09,20万,在研。

3.福州市卫生计生系统科技计划创新团队培育项目(2017-S-wt2),Ku80通过SALL4调控肝癌细胞干性,2017/08-2020/07,8万元,在研。

4. 福建省医学创新课题(2016-CX-48) SALL4在肝癌细胞 DNA损伤修复中的作用研究,2016/10-2019/09,12万元,在研。

5. 福建省自然科学基金面上项目(2016J01417),10-23 型脱氧核酶靶向SALL4 抑制肝癌细胞侵袭转移的实验研究,2016/04-2019/04,5万元,已结题。

6. 福州市科技计划项目(2015-S-143-19),靶向SALL4基因的microRNA对人肝癌细胞恶性表型的影响,2015/04-2018/03,3万元,已结题。

7. 国家自然科学基金青年项目(81302069),Cx32通过p53信号通路调控肝癌细胞侵袭转移,2014/01-2016/12,24万元,已结题。

8. 中国博士后科学基金面上项目(2013M531550),CX32通过p53和Akt信号通路调控肝癌细胞增殖与侵袭转移,2013/01-2015/01,5万元,已结题。

9. 福建省自然科学基金青年创新项目(2012D055),细胞连接蛋白connexin32在肝癌发生发展中的作用研究,2012/07-2013/11,4万元,已结题。


发表论文情况:

(1) Bixing Zhao#, Yingchao Wang#, Xionghong Tan, Kun Ke, Cuilin Zhang, Yunzhen Gao, Naishun Liao, Yuan Dang, Yingjun Shi, Youshi Zheng, Xiaolong Liu & Jingfeng Liu, An optogenetic controllable T cell system for hepatocellular carcinoma immunotherapy. Theranostics. 2019; 9(7): 1837-1850.

(2) Zhao, B., Wang, Y., Tan, X., Ke, K., Zheng, X., Wang, F., Lan, S., Liao, N., Cai, Z., Shi, Y., Zheng, Y., Lai, Y., Wang, L., Li, Q., Liu, J., Huang, A., and Liu, X.  Inflammatory Micro-environment Contributes to Stemness Properties and Metastatic Potential of HCC via the NF-kappaB/miR-497/SALL4 Axis. Molecular therapy oncolytics. 2019; 15, 79-90

(3) Bixing Zhao#, Xiaoyuan Zheng#, Xionghong Tan, Kun Ke, Fei Wang, YingchaoWang, Xiaohua Xing, Cuilin Zhang, Ping Hu, Shubing Lan, Qin Li, Aimin Huang*, and Xiaolong Liu*. Ku80 negatively regulates the expression of OCT4 via competitive binding to SALL4 and promoting lysosomal degradation of OCT4. The International Journal of Biochemistry & Cell Biology. 2020,118: 105664.

(4) Xing X, Yuan H, Sun Y, Ke K, Dong X, Chen H, Liu X, Zhao B* & Huang A*. ANXA2Tyr23 and FLNASer2152 phosphorylation associate with poor prognosis in hepatic carcinoma revealed by quantitative phosphoproteomics analysis. J Proteomics. 2019, 200:111-122.(通讯作者)

(5) Hongzhi Liu#, Hui Chen#, Xiaomo Wu, Ying Sun, Yingchao Wang, Yongyi Zeng , Geng Chen, Xiaolong Liu, Xiaohua Xing*, Bixing Zhao* & Jingfeng Liu, The serum proteomics tracking of hepatocellular carcinoma early recurrence following radical resection. Cancer Management and Research. 2019;11: 2935-2946 (通讯作者).

(6) Shubing Lan#, Xiaoyuan Zheng#, Ping Hu, Xiaohua Xing, Kun Ke, Fei Wang, Niangmei Cheng, Qiuyu Zhuang, Xiaolong Liu, Jingfeng Liu, Bixing Zhao*, Yingchao Wang*. Moesin facilitates metastasis of Hepatocellular carcinoma cells by improving invadopodia formation and activating β-catenin/MMP9 axis. Biochem Biophys Res Commun. 2020 Feb 10. doi: 10.1016/j.bbrc.2020.01.157. (通讯作者).

(7) Youshi Zheng#, Naishun Liao#, Yuan Wu, Ju Gao, Zhenli Li, Wenwen Liu, Yingchao Wang, Ming Li, Xiaolou Li, Li Chen, Wenmin Zhang* & Bixing Zhao*, High expression of B7H2 or B7H3 is associated with poor prognosis in hepatocellular carcinoma, Molecular Medicine Reports. 2019; 19: 4315-4325. (通讯作者)

(8) B. Zhao, W. Zhao, Y. Wang, Y. Xu, J. Xu, K. Tang, S. Zhang, Z. Yin, Q. Wu, and X. Wang*, Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways. Oncotarget, 2015. 6(12): p. 10116-33.

(9) B. Zhao, H. Chen, X. Du, J. Luo, J. He, R. Wang, Y. Wang, R. Wu, R. Hou, M. Hong, and Q. Wu*, Orphan receptor TR3 enhances p53 transactivation and represses DNA double-strand break repair in hepatoma cells under ionizing radiation. Mol Endocrinol, 2011. 25(8): p. 1337-50.

(10) B. Zhao, H. Chen, N. Lei, G. Li, W. Zhao, Y. Zhan, B. Liu, S. Lin, and Q. Wu*, p53 mediates the negative regulation of MDM2 by orphan receptor TR3. EMBO J, 2006. 25(24): p. 5703-15.

(11) X.Lin#, B. Zhao#, H. Chen, X. Ye, C. Yang, H. Zhou, M. Zhang, S. Lin, and Q. Wu, RXRalpha acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells. J Cell Sci, 2004. 117(Pt 23): p. 5609-21.

(12) 王珊,王菲,郑晓源,赵必星*. 靶向SALL4脱氧核酶抑制肝细胞癌恶性表型的实验研究.山西医科大学学报,2019(11):1499-1504 (通讯作者)

(13) 赖永平,曾金华,谭雄红,柯坤,赵必星*,成簇规律间隔的短回文重复序列及其相关蛋白9敲除Ku80基因提高HEK293T细胞对阿霉素的敏感性, 中华实验外科杂志, 2018, 35(8): 1437-1440 (通讯作者)

(14) Xiaohua Xing, Hui Yuan, Ying Sun, Kun Ke, Xiuqing Dong, Hui Chen, Xiaolong Liu, Bixing Zhao*, Aimin Huang*. Dataset for quantitative phospho-proteomics analysis of a serial hepatoma cell lines with increasing invasion and metastasis potential. Data in Brief, 2019; 27:104634.

(15) Lin X, Huang Y, Sun Y, Tan X, Ouyang J, Zhao B, Wang Y, Xing X, Liu J*. 4E-BP1Thr46 Phosphorylation Association with Poor Prognosis in Quantitative Phosphoproteomics of Portal Vein Tumor Thrombus Revealed that 4E-BP1Thr46 Phosphorylation is Associated with Poor Prognosis in HCC. Cancer Management and Research, 2020, 12: 103-115.

(16) Y Wang#, G Wang#, X Tan#, K Ke, B Zhao, N Cheng, Y Dang, N Liao, F Wang, X Zheng, Q Li, X Liu*, J Liu*. MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53. Oncogenesis, 2019, 8(12):67.

(17) Liao, N., Shi, Y., Zhang, C., Zheng, Y., Wang, Y., Zhao, B., Zeng, Y., Liu, X*, and Liu, J*. Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion. Stem cell research & therapy. 2019; 10:306

(18) Zhang Xiang; Wang Fei; Huang Yanbing; Ke Kun; Zhao Bixing; Chen Lihong; Liao Naishun; Wang Lei; Li Qin; Liu Xiaolong; Wang Yingchao & Liu Jingfeng*. FGG promotes migration and invasion in hepatocellular carcinoma cells through activating epithelial to mesenchymal transition. Cancer Management and Research. 2019;11:1653-1665

(19) Liu Z, Wu S, Wang L, Kang S, Zhao B, He F, Liu X, Zeng Y, Liu J*. Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis. Dis Markers. 2019: 2491291. doi: 10.1155/2019/2491291.

(20) Ke K, Chen G, Cai Z, Huang Y, Zhao B, Wang Y, Liao N, Liu X, Li Z, Liu J*. Evaluation and prediction of hepatocellular carcinoma prognosis based on molecular classification. Cancer management and research, 2018, 10: 5291-5302.

(21) Yan, S., Cui, S., Ke, K., Zhao, B., Liu, X., Yue, S., & Wang, P*. Hyperspectral stimulated Raman scattering microscopy unravels aberrant accumulation of saturated fat in human liver cancer. Analytical chemistry. 2018; 90: 6362?6366

(22) Wu, M., Lin, X., Tan, X., Li, J., Wei, Z., Zhang, D., Zheng, Y., Zheng, A., Zhao, B., ... & Liu, X*. Photo-responsive Nanovehicle for Two Independent Wavelength Light-Triggered Sequential Release of P-gp shRNA and Doxorubicin to Optimize and Enhance Synergistic Therapy of Multidrug-resistant Cancer. ACS applied materials & interfaces. 2018, 10(23): 19416-19427.

(23) Wu, M., Li, J., Lin, X., Wei, Z., Zhang, D., Zhao, B., ... & Liu, J*. (2018). Reduction/photo dual-responsive polymeric prodrug nanoparticles for programmed siRNA and doxorubicin delivery. Biomaterials science, 6(6), 1457-1468.

(24) Liao, N., Zheng, Y., Xie, H., Zhao, B., Zeng, Y., Liu, X., & Liu, J. (2017). Adipose tissue-derived stem cells ameliorate hyperglycemia, insulin resistance and liver fibrosis in the type 2 diabetic rats. Stem cell research & therapy, 8(1), 286.

(25) Wei, Z., Lin, X., Wu, M., Zhao, B., Lin, R., Zhang, D. Zhang, Y., Liu, G., Liu, X. & Liu, J*. Core-shell NaGdF 4@ CaCO 3 nanoparticles for enhanced magnetic resonance/ultrasonic dual-modal imaging via tumor acidic micro-enviroment triggering[J]. Scientific Reports, 2017, 7(1): 5370.

(26)W. Chen, L. Chen, Z. Cai, D. Liang, B. Zhao, Y. Zeng, X. Liu, and J. Liu*, Overexpression of annexin A4 indicates poor prognosis and promotes tumor metastasis of hepatocellular carcinoma. Tumour Biol, 2016,37(7):9343-55

(27) W. Zhao, Y. Xu, J. Xu, D. Wu, B. Zhao, Z Yin, and X. Wang*. Subsets of myeloid-derived suppressor cells in hepatocellular carcinoma express chemokines and chemokine receptors differentially. Int Immunopharmacol. 2015. 26(2): p.314-21.

(28) W. Zhao, L. Zhang, Y. Xu, Z. Zhang, G. Ren, K. Tang, P. Kuang, B. Zhao, Z. Yin, and X. Wang*, Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model. Lab Invest, 2014. 94(2): p. 182-91.

(29) W. Wang, Y. Wang, H. Chen, Y. Xing, F. Li, Q. Zhang, B. Zhou, H. Zhang, J. Zhang, X. Bian, L. Li, Y. Liu, B. Zhao, Y. Chen, R. Wu, A. Li, L. Yao, P. Chen, Y. Zhang, X. Tian, F. Beermann, M. Wu, J. Han, P. Huang, T. Lin, and Q. Wu*, Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol, 2014. 10(2): p. 133-40.

(30) S. Zhang, X. Wang, Z. Yin, W. Zhao, J. Zhou, B. Zhao, and P. Liu*, Chloride intracellular channel 1 is overexpression in hepatic tumor and correlates with a poor prognosis. APMIS, 2013. 121(11): p. 1047-53.

(31) R. Wang, J. He, M. Su, J. Luo, M. Xu, X. Du, H. Chen, W. Wang, Y. Wang, N. Zhang, B. Zhao, W. Zhao, Z. Shan, J. Han, C. Chang, and Q. Wu*, The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling. EMBO Mol Med, 2013. 5(1): p. 137-48.

(32) H. Chen, L. Li, W. Wang, X. Du, Q. Wen, J. He, B. Zhao, G. Li, W. Zhou, Y. Xia, Q. Yang, C. Hew, Y. Liou, and Q. Wu*, Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis. Oncogene, 2012. 31(23): p. 2876-87.

(33) Y. Zhan, X. Du, H. Chen, J. Liu, B. Zhao, D. Huang, G. Li, Q. Xu, M. Zhang, B. Weimer, D. Chen, Z. Cheng, L. Zhang, Q. Li, S. Li, Z. Zheng, S. Song, Y. Huang, Z. Ye, W. Su, S. Lin, Y. Shen, and Q. Wu*, Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol, 2008. 4(9): p. 548-56.

(34) H. Chen, B. Zhao, W. Zhao, L. Li, B. Zhang, and Q. Wu*, Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria. Carcinogenesis, 2008. 29(11): p. 2078-88.

(35) W. Zhao, M. Tian, B. Zhao, G. Li, B. Liu, Y. Zhan, H. Chen, and Q. Wu*, Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor-alpha. Mol Endocrinol, 2007. 21(12): p. 2877-89.


授权发明专利:

1. 刘小龙,赵必星,刘景丰,谭雄红。一种光调控T细胞活化的表达载体、构建方法及应用。专利号:ZL 2016 1 0404536.9


荣誉与奖励:

2020年 第四届福州青年科技奖

2013年 福建省自然科学奖一等奖,《孤儿受体TR3通过信号转导通路抑制肿瘤细胞生长的新机制》,排名第4

2012年 厦门市科技进步一等奖,《原发性肝癌的基础与临床应用研究》,排名第8

2008年 福建省自然科学优秀学术论文二等奖,《P53介导孤儿受体TR3对MDM2的负调控》