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团队成员

郑爱仙

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郑爱仙:理学博士,福建医科大学孟超肝胆医院助理研究员,硕士生导师。主要从事癌症标志物检测新方法研究以及肿瘤成像与治疗新方法研究。主持国家自然科学基金青年项目、中国博士后科学基金面上项目、福建省自然科学基金、福建省卫生健康中青年骨干人才培养项目等多项国家级和省市级研究课题,以第一作者或通讯作者发表SCI论文十几篇。


研究方向

癌症标志物检测、肿瘤分子影像、肿瘤免疫治疗

主持承担的科研项目:

1. 福建省卫生健康中青年骨干人才培养项目,2019-ZQN-88,基于响应型荧光探针的肿瘤微环境荧光成像方法研究,2019/09-2022/08,8万元,主持。

2. 中国博士后科学基金面上项目,2018M642557,新型近红外荧光探针用于肿瘤微环境特异响应的成像研究, 2018/09-2021/08,5万,主持。

3. 国家自然科学基金青年项目,21705022,核酸功能化聚多巴胺纳米探针在miRNA响应的肿瘤成像与治疗中的应用研究,2018/01-2020/12,20万,主持。

4. 福建省科技创新联合资金项目,2017Y9115,核酸功能化纳米探针在高灵敏成像分析中的应用研究, 2017/12-2020/12,15万,主持。

5. 福建省自然科学基金项目,2016J05207, 肿瘤相关microRNA响应的肝癌成像与治疗一体化研究,2016/04-2019/04,3万元,已完结,主持。

6. 福州市科技计划项目,2016-S-124-13,癌症相关microRNA响应的核酸纳米探针在肿瘤成像与治疗中的应用研究,2016/03-2018/03,3万元,已完结,主持。

7. 福州市卫生系统科技计划项目,2015-S-wq9,染料增强的多功能光热转换纳米材料在肝癌靶向治疗中的应用研究,2015/12-2018/11,2万元,已完结,主持。

8. 福建省卫生计生委青年科研课题,2015-1-95,基于多功能纳米材料的肝癌相关蛋白检测新方法研究,2015/01-2018/12,2万元,已完结,主持。

代表性论文:

1. Yanlin Du, Hui Liu, Jiaming Liang, Dongye Zheng, Jiong Li, Shubing Lan, Ming Wu, Aixian Zheng*, Xiaolong Liu*. Protein-assisted formation of gold clusters-MnO2 nanocomposite for fluorescence imaging of intracellular glutathione. Talanta, 2020, 209, 120524. (通讯作者)

2. Jing Wang, Hui Liu, Ming Wu, Xiaolong Liu, Haiyan Sun*, Aixian Zheng*. Water-soluble organic probe for pH sensing and imaging. Talanta, 2019, 205, 120095.(通讯作者)

3. Lei Fu#, Yanlin Du#, Zhenxi Zhang, Haiyan Sun, Aixian Zheng*, Xiaolong Liu*. Dual sensing of glutathione and acidic pH values by using MnO2 nanosheets and 3-acetyl-7-hydroxy-2H-chromen-2-one as a fluorescent pH probe, Microchimica Acta, 2019, 186, 491. (通讯作者)

4. Ying Sun, Hui Liu, Xionghong Tan, Zheng Li, Yanlin Du, Aixian Zheng*, Xiaolong Liu* and Niancai Peng*, Highly efficient redox reaction between potassium permanganate and 3,3’,5,5’-tetramethylbenzidine for application in hydrogen peroxide based colorimetric assays. RSC Advances, 2019, 9, 1889-1894.(通讯作者)

5. Aixian Zheng, Xiaolong Zhang, Yanbing Huang, Zhixiong Cai, Xiaolong Liu, Jingfeng Liu*, Polydopamine-assisted versatile modification of a nucleic acid probe for intracellular microRNA imaging and enhanced photothermal therapy. RSC Advances, 2018, 8, 6781-6788.

6. Aixian Zheng, Xiaolong Zhang, Ju Gao, Xiaolong Liu*, Jingfeng Liu*, Peroxidase-like catalytic activity of copper ions and its application for highly sensitive detection of glypican-3. Analytica Chimica Acta, 2016, 941, 87-93.

7. Aixian Zheng, Da Zhang, Ming Wu, Huanghao Yang, Xiaolong Liu*, Jingfeng Liu*, Multifunctional human serum albumin-modified reduced graphene oxide for targeted photothermal therapy of hepatocellular carcinoma. RSC Advances, 2016, 6, 11167-11175.

8. Yongyi Zeng#, Aixian Zheng#, Jing Wu, Zhixiong Cai, Aimin Huang*, Xiaolong Liu*, Horseradish peroxidase and aptamer dual-functionalized nanoprobe for the amplification detection of alpha-methylacyl-CoA racemase. Analytica Chimica Acta, 2015, 899, 100-105. (共同第一作者)

9. Ai-Xian Zheng, Zhong-Xiao Cong, Jin-Ru Wang, Juan Li, Huang-Hao Yang*, Guo-Nan Chen, Highly-efficient peroxidase-like catalytic activity of grapheme dots for biosensing. Biosensors and Bioelectronics, 2013, 49, 519-524.

10. Ai-Xian Zheng, Jin-Ru Wang, Juan Li, Xiao-Rong Song, Guo-Nan Chen, Huang-Hao Yang*, Enzyme-free fluorescence aptasensor for amplification detection of human thrombin via target-catalyzed hairpin assembly. Biosensors and Bioelectronics, 2012, 36, 217-221.

11. Ai-Xian Zheng, Juan Li, Jin-Ru Wang, Xiao-Rong Song, Guo-Nan Chen, Huang-Hao Yang*, Enzyme-free signal amplification in the DNAzyme sensor via target- catalyzed hairpin assembly. Chemical Communications, 2012, 48, 3112-3114.

12. Ai-Xian Zheng, Jin-Ru Wang, Juan Li, Xiao-Rong Song, Guo-Nan Chen, Huang-Hao Yang*, Nicking enzyme based homogeneous aptasensors for amplification detection of protein. Chemical Communications, 2012, 48, 374-376.


获奖情况:

1. 刘景丰、刘小龙、王红阳、曾永毅、陈磊、黄爱民、曾金华、蔡志雄、郑爱仙、邢晓华,肝细胞癌早期诊断和预后判断的分子标志物筛选及临床应用,福建省科学技术奖一等奖,2019年9月。